Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4595)
Related Products (4595)
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BuChE-IN-22
0 ImagesCat. No.: HY-181865BuChE-IN-22 is a pseudo-irreversible butyrylcholinesterase (BuChE) inhibitor, with IC50 values of 4 nM and 157 nM against hBuChE and hAChE, respectively. It also acts as a prodrug of 7-hydroxysertraline. BuChE-IN-22 releases 7-hydroxysertraline during BuChE inhibition. BuChE-IN-22 completely reverses Aβ25-35-induced short-term and long-term memory impairments in a mouse model of Alzheimer's disease. BuChE-IN-22 can be used in research related to Alzheimer's disease.
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VYPFPGPIHN
0 ImagesCat. No.: HY-P11740CAS No.: 157173-35-8VYPFPGPIHN is a precursor peptide of β-casomorphin (HY-P0179) and also an ACE inhibitor (IC50 = 123 μM). VYPFPGPIHN resists hydrolysis by peptidases associated with intestinal cell monolayers, maintaining structural integrity and ACE inhibitory activity. VYPFPGPIHN is not extensively taken up or transported by differentiated intestinal cell monolayers.
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Desalkylquazepam
0 ImagesCat. No.: HY-W664824CAS No.: 1645-32-5Synonyms: N-DesmethylquazepamDesalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines. Desalkylquazepam is a mAChR modulator (EC 50 = 0.317 µM).
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1H-Pyrazole-3,4,5-d3
0 Images1H-Pyrazole-3,4,5-d3 is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities.
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9(S)-HPETE
0 ImagesCat. No.: HY-180604CAS No.: 126873-47-09(S)-HPETE is an intermediate in the biosynthesis of dictyopterene A in the freshwater diatom Gomphonema parvulum.
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Fmoc-PNA-maleimide-OH
0 ImagesCat. No.: HY-P11697CAS No.: 1445566-02-8Fmoc-PNA-maleimide-OH is a Fmoc-protected functionalized peptide nucleic acid monomer featuring a maleimide group for thiol-reactive conjugation. Fmoc-PNA-maleimide-OH can be used in constructing PNA conjugates for molecular assembly applications.
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Carzelesin
0 ImagesCat. No.: HY-19601CAS No.: 119813-10-4Synonyms: U 80244Carzelesin is a cyclopropylpyrroloindole precursor molecule and effectively inhibits tumor growth. Carzelesin may be used in cancer research.
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Tetrahydrocortisone acetate
0 ImagesCat. No.: HY-148379CAS No.: 17736-20-8Tetrahydrocortisone acetate is a intermediate product for production of tetrahydrocortisone 3-glucuronide.
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β-L-Fucopyranosyl phosphate
0 ImagesCat. No.: HY-145781CAS No.: 16562-59-7β-L-Fucopyranosyl phosphate can be used for the research of carbohydrate metabolism. Glycosyl phosphates play crucial roles in carbohydrate metabolism as metabolic regulators or ubiquitous intermediates for glycoconjugate biosynthesis.
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Neurosporene
0 ImagesCat. No.: HY-W750719CAS No.: 502-64-7Neurosporene is a carotenoid. Neurosporene is an intermediate in the synthesis of Lycopene (HY-N0287). Neurosporene can be isolated from date palm, Kocuria sp. GMA bacteria, and Anthurus archeri fungi. Neurosporene has antioxidant activity. Neurosporene can be used in the research of diseases such as cancer.
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Sar10
0 ImagesCat. No.: HY-203876CAS No.: 2375600-72-7Sar10 (Compound 1) is a component of a bicyclic peptide sequence (βAla-Sar10-A-) for synthesis of multimeric CD137-binding/activating bicyclic peptide ligands.
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G256
0 ImagesCat. No.: HY-177148CAS No.: 134867-97-3G256 is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 can be used for research on arrhythmias.
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N-Hydroxytyrosine
0 ImagesCat. No.: HY-180746CAS No.: 64448-49-3N-Hydroxytyrosine is an early intermediates in the conversion of tyrosine to p-hydroxymandelonitrile.
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γ-Glutamyl-S-(2-carboxypropyl)cysteine monoTFA (Standard)
0 ImagesCat. No.: HY-182089BRγ-Glutamyl-S-(2-carboxypropyl)cysteine monoTFA (Standard) is the analytical standard of γ-Glutamyl-S-(2-carboxypropyl)cysteine monoTFA. This product is intended for research and analytical applications. γ-Glutamyl-S-(2-carboxypropyl) cysteine TFA is a chemical intermediate. γ-Glutamyl-S-(2-carboxypropyl) cysteine can be used in the synthesis of Alliin (HY-N0661) and Isoalliin (HY-111825A).
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16S,22S-Dihydroxycholesterol
0 ImagesCat. No.: HY-N20657CAS No.: 1644058-82-116S,22S-Dihydroxycholesterol is a stereospecific dihydroxylated cholesterol and also a key intermediate in the biosynthesis of Diosgenin (HY-N0177) in plants.
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FSY-OSO2F
0 ImagesCat. No.: HY-163281CAS No.: 1839622-49-9
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3'-NH-Tr-2',3'-dT-5'-
CE-Phosphoramidite
0 ImagesCat. No.: HY-W1119948CAS No.: 195375-68-93'-NH-Tr-2',3'-dT-5'-CE-Phosphoramidite is a special phosphoramidite compound used in the synthesis of oligonucleotides and nucleic acid analogs. 3'-NH-Tr-2',3'-dT-5'-CE-Phosphoramidite can be used in antiviral and anticancer research.
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Erlotinib lactam impurity
0 ImagesErlotinib lactam impurity (compound 7a) is a precursor of the tyrosine kinase inhibitor.
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Fosamprenavir-d4
0 ImagesCat. No.: HY-78726SCAS No.: 1133702-41-6Synonyms: Amprenavir phosphate-d4; GW 433908-d4Fosamprenavir-d4 is the Deuterium-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection.
